OK My brother and now sister-in-law just went through this. They were only just married this past summer. I had kept my mouth shut though I have my well founded suspicions. For example She claims she's pregnant, my brother then agrees to marry her, then miscarries, then less than 4 weeks after she supposedly miscarries she's miraculously pregnant again. Highly unlikely. Not counting the other 4 times she mislead my brother trying to trap him into marriage and then suddenly miscarries every time. He never seeing anything of it the pregnancy or miscarriage or hearing of it from the Dr.
Anyway this isn't about my SIL or brother. He's just an example. It's about your's. If she is screwing with your brother, whether he's mature enough to realise it or not you need to just leave well enough alone. He will resent you for "breaking" up their relationship when it eventually goes. You will make an enemy out of the brother you are trying to protect. The most I can imagine doing is talking to your brother saying "Hey This looks so suspicious. Do you really think you can trust her? Do you really want to stick with this?" If he says yes then let it be. Say that you are just worried about things but it's his business not yours and tell him that if things happen to not work out you will be there to lend a hand or ear or shoulder. Tell him you wish him all the luck in the world.
DON'T go to her. If she is being a bitch she will continue being a bitch and might use your "accusations" against you by sharing with your brother or whining to friends and family. Who knows.
It's very possible that this relationship won't last. Just be there for your brother and niece and don't make any enemies along the way. Stand up for your brother if you are ever around when the dam breaks loose but don't stand in his way.
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"Always learn the rules so that you can break them properly." Dalai Lama
My Karma just ran over your Dogma.
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