As far as Rivers is concerned, perhaps old(er) age and a harvard degree have influenced his thought process more than fame has. Musical inspiration comes from personal experience, and when your life changes so drastically, so might the music.
More generally, Fame changes self-perception and the people around you. Many people go through life seeking approval, and when fame comes along, they are suddenly faced with more approval than they can handle. When pleasing others ceases to be a struggle, you are free to act differently. For some people anyway. Others become cynical about the sort of "fake" approval they receive. Kurt Cobain fits into this category.
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