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I agree with other folks that you will need to change your mindset before your situation can change - if you go do something different without altering your attitude, it'll be "different place, same old shit." You need to realize that you are in control of your life, of the choices that you make right now. You can't go back and change things but you can change things now, and from what it sounds like it's not too late by any stretch of the imagination. What are your interests? What are your dreams? Your passions? Choose one, or find one, and pursue it.
One other thing that might help you is to get "outside yourself" a little bit - forget your own problems by doing things for other people. Join some volunteer groups that help out others - work for the local food bank, habitat for humanity, elder care, whatever. You'll meet a lot of interesting and caring people, you'll be needed and welcome, and it might help you recognize that you have something to contribute.
Lastly (actually this should have been first but I forgot) seek help for the depression. It sounds like you have carried this around for a while, and you may have sought treatment before and had it fail. Try again. If you're on meds, it's clear they're not working and you might need a different med or different doseage. Try therapy, as well, if you can. It sounds like you have some harmful thought patterns that are well-established and have you firmly by the short and curlies.
Good luck, and remember that your life is yours. You're in charge.
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"If ten million people believe a foolish thing, it is still a foolish thing."
- Anatole France
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