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For me I'd have to say end it when you realize you are spending less time happy than you think you should, when you really start worrying about things he/she is doing/may do, when you find your life consumed with him/her (against your wishes of course). I think that especially if you arent happy and have told the person this and nothing has changed, it might be a clue that you should start thinking about ending it on a mutual agreement.
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