Totally agreed with twisted mosaic. What it feels like losing your best friend, is in Shadow of the Colossus. Because you're seemingly the only human being in a world so different and dangerous, with opponents as big as mountains, you get used to having an ally you need and trust.
What else. The ending of Metal Gear Solid 3, when all the flowers in the field turn red after the fight with The Boss. I've rarely seen something as beautiful and poignant as that scene. Still my favorite MGS game by far.
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