It all depends on what is important to you and your relationships. I think if someone is the polar opposite of your core fundamental values and beliefs then it is virtually impossible for you to maintain a genuine close relationship with them. As far as religion and politics, it all depends on the other person. I easily navigate with conservative and liberal friends, since I grew up a conservative and like the statistics say, was made liberal by higher education. Religion is a topic I tend to stay away from, I'd rather not shatter the dreams of people who still haven't rationally thought out the Bible.
I agree with abaya, if one of my close friends was constantly cheating on his girl or somehow hurting or using other people then I would have to rethink my relationship with them. Maybe I'd still hang out with them but I wouldn't hold them in the same regard and know that they would screw me over if it meant getting themselves ahead.
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