Depending on the speed of your computer, you could try The Eldar scrolls Oblivion, or it's predecessor, Morrowind. There's not necessarily a lot of humor in there, but these are games you can play for ages.
If you're pc is up to it, I can also recommend Vampire the masquerade: bloodlines, if you can put up with not-so-perfect video speed and the occasional hiccup. If you play as a Malkavian ("crazy") vampire, you'll have some of the funniest dialogue options in gaming history... It also has a very good story line.
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