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I'm on such a low dose that if I miss taking it at night and remember the next morning, not even 12 hours late, I will begin spotting. Also stress, lack of sleep, illness, anything that drags you down physically can affect your own hormone levels and cause some spotting. If you spot for more than 2 weeks (in my opinion) you should call your Dr. Some people do better with one formula of hormones than they do on another. Good Luck.
Do a search and you will find a number of threads on this subject.
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