The folder of which you speak is only temp Internet stuff and it can all go. However, you MUST be aware that your cookies are not stored there, so there may be other stuff on your system you may want to get rid of.
Crap Cleaner is okay, but I use
iISystem Wiper for all those IE files, and I use AdAware for adware problems, and SpyBot for spyware problems. FireFox has all of these things built in nicely, so when I browse with that I have no problems.
At home, my problems are even less as I run Ubuntu Linux, and there is far less crap in there.
But, in the final analysis, you should do something to get rid of this stuff.
Peace,
Pierre