Different from Jesus Pimp's similarly titled thread in that I'm not talking about religion. A few of these directly relate to each other, so... here they are. Oh, and I'm not suggesting that all of these are going to happen next year, but they're (most likely) going to be a factor before long.
1) Isn't there a couple meteors coming through our solar system? A couple of really big ones, one in 2019 and one in 2800? They may not hit us, but if they pass through our solar system, they'll throw off the orbits of the planets.
2) Overpopulation. More and more people arriving here on earth, and less and less space to put them. That's a problem.
3) Depletion of natural resources. What's the fuel that probably pops into your mind first? Oil. Oil takes a long time to form, and we don't have that time. We don't have a backup fuel. Also in the natural resource category is water. With the rise of overpopulation, here comes a water shortage.
4) Crazy dictators with nukes. With so many countries with nukes, it can't be long before they go off.
I'm sure that there are more, but this is all I could think of. Oh well, look on the bright side of life