my two cents:
1) N64 games are a little weird with ps/ps2 controller
2) Unless your running the games to a TV, playing 2P in front of the pc isn't comfortable.
3) If you want to do 2P on a PC, I'd use 2 PCs <a href="http://www.kaillera.com/download.php" target="_blank">*kaillera*<a>