This doesn't really count, but a friend of mine made a spaceship dogfighting game called "Orion" back in HS. One of the weapons you could arm your ship with was the "People Gun". You fired stick men (your own crew) at the enemy, it cost you some of your health, but it did more damage to your opponent.
Nothing says "You got served" like beating someone with the People gun.
For games that everyone's played, I nominate the wind-up shoe from SMB3.
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