Make sure that your sound card and your USB Controller / Mouse&Keyboard are not using the same IRQ if possible, this could cause something like this. I would be truly suprised though, because the last time I seen a problem like this was back in Win98 with a old 486 and a limited amount of resources, The Serial mouse was interfearing with the modem, so if you moved the mouse, the modem would stop dead in its tracks in the middle of dialing up. Also check the Equalizer on your software you are using to play the MP3s. Are you able to take out your powersupply and replace it with a known good one? Perhaps it is not producing clean power and causing this? Also make sure your box does not have any kind of electrical pulse through it. THey are used as a Ground for most systems and if there was an issue with power, the case could become energised MABY? cause this kinda problem.
Anyway I am just listing off a few things hehe Gluck, and I will try some other things and let you know.
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