If anything with Depo, I have slightly decreased sex drive. But nothing overly noticible though. Sometimes, I just don't feel like it ... but that always may be attributed to other factors such as stress.
I'd love to go on this seasonale thing, as I like the idea that I can actually have a period every once in awhile (because on Depo without periods, I always wonder if I'm pregnant even if I have no chance) .. but my periods were always so painful I couldn't stand it any longer