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I'd say that some big threats to mankind are:
1) conservatives (*real* ones!). They like the old, and don't want things to ever change. This leads to stagnation of scientific research, amongst other things, and a premature end to a potential to safe us all.
2) organized religion (including extremists). inherently conservative, because change might proof the holy books wrong. What's worse, these guys might fight to stop that change.
3) humans. we're typically a bunch of greedy bastards, out to further our own causes. That will prove deadly when all of us have to work together to safe our planet and race.
but the biggest threats to mankind are...
4) people who just want to do the right thing. "Hey, I might have accidentally set free a bunch of diseased killer mutant labrats that will kill all humans within a week, but I was just doing the right thing!"
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