Never done it myself, but have always been interested in it. A few friends have done it, and most of them wont ever do it again.
There are a few stories of profound experiences amongst it all. If you go to erowid or somewhere, you'll find a mixed bag of results.
Without having done it myself, I couldn't recommend anyone to steer clear or go and experiment. I can advise you to exercise caution though, as you should with any substance.
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