Phred, don't worry too much about the I-40 through the Tn/NC Mountains as long as you can check a forecast for Asheville, NC and verify no snow, you won't have trouble. The road is plowed if there is a snowfall, so worst case, you might have to hold in Knoxville or just go north on I-81 as suggested if you get that far and find it's shut down. But this time of year, I think you'll be ok. March is usually the heavy time for snow.
Have a safe trip!
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