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jeesh, I think not getting off would give me depression! Seriously I echo all that have said talk to the Doc. There are many SSRI's (Selective Seratonin Reuptake Inhibitors) out there but they don't all work the same way (to be honest even the scientists are not exactly sure how they work!). Hate to play trial and error with your body, but you have to weigh your wife's total well being with all the possible solutions. Good luck.
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"Religion is the one area of our discourse in which it is considered noble to pretend to be certain about things no human being could possibly be certain about"
--Sam Harris
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