I can vouch for Charleston, SC. Yoshi lived there when we were dating, so I was down at least once a month. It's still one of our favorite cities - and we're doing our damndest to live there full time. United has direct flights, I believe.
If you're looking for a little closer to home, what about the Smoky Mountains? A B&B in the woods as the leaves change?
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"If you're walking on thin ice, you may as well go ahead and dance."
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