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the T in DMT stands for tryptamine, which is a basic structural molecule that is the parent structure for many psychoactive compounds. serotonin, which regulates many of our normal biological functions, is 5-hydroxy tryptamine. 5-methoxy-N,N-dimethyltryptamine is 5-MeO-DMT. the structural similarity allows the DMT molecule to fit into the serotonin receptor and mix up any signal that was trying to be sent across the synapse. many other hallucinogens are active in the same manner as 5-MeO-DMT. Psilocybin, the psychoactive compound in shrooms, is 4-phosphoryloxy-N,N-DMT. LSD, though not a tryptamine compound, also effects serotonin receptors.
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Psychoactive drugs generally have two functions when they bind to receptors. They either plug into the receptor and mimic neurotransmitter action (agonist) or they block access or neurotransmitters and other drugs without carrying on neurotransmission (antagonist). LSD and presumably other tryptamine hallucinogens (yes, LSD is a tryptamine) act as agonists at the 2A and 2C subclasses of serotonin receptors to exert their hallucinogenic effects. Also, there are several psychoactive chemicals in mushrooms that produce hallucinogenic effects.
I was just curious about the more advanced pharmacology of 5-MeO-DMT as I have read next to nothing on the subject (yet). I've only used it once, high-dose, very interesting.