Use what you like, or use neither. There are lots of choices out there, and not using one doesn't limit you. You can run KDE apps in GNOME or GNOME apps in KDE. You can run them both in Enlightenment, or icewm, or whatever you want. Just play around and see which you like more
I personally run a cvs of Enlightenment 0.16.6 and do most of my app launching from terminals. That's the beauty of Linux. You have the choice.