Quadrette took it when we first started dating. She had similar experiences to the ones above. I asked her to contribute her opinion to this thread, so here it is:
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i took depo for about 1 year, maybe a little less. at first, it was great - one shot for 3 mos, and i never thought about it again. there was some weight gain, but not enough for me to care. i didn't notice too much in terms of emotional roller coaster issues - but then, i was melodramatic to begin with.
it didn't even strike me as weird to not have a period at all - i was delighted! but after about 6 mos or so, i started getting random bleedthrough action - a little here or there is fine, but when you suddenly realize you've ruined your new boyfriend's sheets (lucky Quadro), it's a little upsetting.
mind you, not EVERYONE has these kinds of issues, but i did. this from a gal who never had much concern over her monthly to begin with - it was always around, but pretty easy to deal with compared to other girls. try it - but the minute you get bleedthrough more than once for more than one week - do something else.
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So there you have it. The spotting just eventually became too much to deal with. She initially took it because she was worried that she wouldn't remember to take a daily pill, but like everything else, it's become second nature.