I've worn a thong before, and will never do it again. I'd rather go commando, I'd rather wear crotchless panties...but to have a thin piece of cloth in between your butt cheeks ain't exactly ideal.
Not that it's uncomfortable but lets face it, that part of your body is dirty and wearing a thong will bring with it many undesireable side effects(think tread marks). And we all know how fond males are of flatulence(sic).
Reminds me of a funny story though. My gf's mom who is quite traditional, was doing her laundry(we were visiting her parents) and found her thongs...she told her mom they were mine...her mom now thinks I'm some sort of pervert