I agree that seeing a counselor might be the best option here, but if she doesn't want to go to a counselor, there are other things you might be able to do.
This is going to sound like a totally dumb suggestion, but take her out walking.
Exercise is about as effective as antidepressants at reducing depressive symptoms in clinical trials. Go walking with her a few times a week, and while you're walking she can talk. Maybe it'll give her a chance to get some things off her chest, and all you really have to do is listen. That's what most people want, anyhow, and that's probably the most valuable aspect of counseling: having someone to spill your guts to. Granted, the other valuable aspect of counseling is having an objective person point out where your thinking is harming you, but you may be able to do that as well if you're comfortable with it.
It's not going to cure all ills, but the walking will take the edge of the chemical side of the depression thing and maybe make it easier for her to deal with the rest of her 16-year-old life.
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"If ten million people believe a foolish thing, it is still a foolish thing."
- Anatole France
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