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Mononucleosis is a fun disease that gives you what's essentially a week-long nightmare fever. (It can last for months.) It's sometimes referred to as The Kissing Disease because it's primarily spread through oral contact. I'm not sure about this, but I think I've heard you can only get it once, like chicken pox.
I remember back in high school there was a small epidemic of mono. Kids would leave school for weeks at a time over the winter and return, somewhat more haggard and way the hell behind, in the spring.
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