Some RPGs can be done mostly with the mouse, especially with Warrier classes that have less hotkeys. Diablo2 might be managable for instance, though some of the slower ones like Baulders Gate might be better, etc.
They might require some tinkering with keys, but at a pace where you could reach over with your other hand without a problem.
World of WarCraft when it comes out is supposed to be the most streamlined interface ever for an RPG. Pure speculation on my part but it might be a great game for mouse only..
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"Convictions are more dangerous enemies of truth then lies." - Nietzsche
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