Shoot. There's a lot of em. but probably Super Metroid. I played the hell out of that. I once beat it in an hour 15 gametime.
runners up being
-Secret of Manna (I actually called the Nintendo Power tipline way back then and informed them of stuff they didn't have on their computers. They promised to send me a mag, but never did
)
Final Fantasy 2 and 3 (US)
Space Megaforce
Castlevania 4