It really bears playing at least twice, and the second time you'll have at least an inkling of what's going on, rather than being constantly mystified by people talking over your head. Or you could do what all good MGS fanboys like me do, and dig up The Document of Metal Gear Solid 2. Has a complete script, with actor's directions and unspoken subtext in it.
Rose is a total shrew. I'll take E.E., personally.
Or maybe Mei Ling.