Depp is great, I love him, and he has been in more movies that I love. He is also much more versitle. That said Walken is the *only* actor (well alive) that can do that creepy thing he does correctly. While he can't really flex out of that roll two well, depp could never step into it either. Nor could anyone else.
My vote goes to Walken.
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Use the star one and you'll be fighting off the old ones with your bare hands
-A Shoggoth on the Roof
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