I'll be making several ten hour trips in the next few weeks, and it was very informative to read this. I plan to load up on music and healthy snack foods.
Breaks where you get out of the car, maybe do some mild calithenics, etc., every few hours, are very important. If you're sitting for a very very long (anywhere, at a computer or in a car) your blood pools and you start getting drowsy.
The best solution is, as a few people said, to bring a friend who can drive, so you can take turns and talk during the trip. Unfortuantely, I (and it sounds like the original poster) will be making solo trips, but the rest of the info should help.
And I love the megaphone idea. I'll have to try that out.
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