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In short, he made it up. It's an interesting theory, but nothing more than that. Most reports of mental impairment in dissociative users come from reeeally heavy usage (5+ times a week) and as far as I know most people generally recover after a year or two of not using it. Sure, even a bit of short-term impairment is bad, but its certainly possible to use dissociatives at levels below those at which impairment seems to be fairly common (not 5+ times a week :P)
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NAN (induced from either dissociative or Diet-drink use) and OL are theoretical risks, such as MDMA neurotoxicity. In reality, I doubt it's a risk worth getting your panties in a bunch over (for humans, anyway). More research would be appreciated though.
However, I will admit that I have heard of impairment in DXM users that used at a maximum way less than five times a week.