I've been using Spybot for what seems like ages but recently added spywareblaster to my list of must haves.
http://www.javacoolsoftware.com/spywareblaster.html
Stops spyware from ever being installed.
Trillian all the way. Fuck I hate ICQ. bloated memory hog.
Pop-up stopper.
Winamp 2.91
ACDSEE 5.01 powerpack
Flashget 1.40
CloneCD
CDMate
Roger Wilco
WinRar
HWDoctor
Sisoft Sandra