When my wife and I met and decided to become intimate, we both were tested for every STD we could think of. Then, with her on the pill, we had plenty of sex for about five years. Then, when we were ready, she went off the pill and four months later, we're now pregnant.
So the pill worked great for us, but we were always worried about the .1% chance that something could happen.
Interestlingly enough, we have friends who, over approximately the same time frame, used the "pull-out method" of birth control. It blows my mind that it worked, but it did for four years, and now they have three beautiful kids.
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