I can attest to the durability of the Camelbak MotherLode. I used it for a year in Afghanistan and it held up really well despite being thrown around inside trucks and manhandled in the countryside. It is comfortable and the zippers didn't fail. What I didn't like: mesh organizer pocket in main compartment, top heavy secondary pocket design makes it fall over all the time when it's not on your back. I'm not sure if they've changed the design since 2006, but the MotherLode isn't designed to take laptops without their own sleeve. The pockets, including the hydration sleeve area, are unpadded.
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