I vote for Toy Story. It pretty much killed traditional animation.
I would like to think that Star wars and Star Trek were up there when it comes to influencing real world change. I know for sure they changed my interests as a kid and influenced my interests are a teen and adult.
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Originally Posted by KellyC
^I would argue that Robin William's Mrs. Doubtfire started the whole thing.
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Dustin Hoffman did it before Robin Williams in Tootsie
Heck, It was done even earlier than that by Jack Lemmon and Tony Curtis. I'd say Martin Laurence was more inspired by Nutty Professor than Tootsie though.