For movie-making it has to be 1973's The Day of the Dolphin. Friendly fun-loving dolphins are taught to communicate properly, in English, by George C Scott only to have bombs strapped onto their strong smooth bodies by shadowy government forces with a nefarious agenda. This landmark film paved the way for other films in which similar animals talked, or acted human, or other things happened, such as Flipper, Andre, and Splash!, E.T. the Extra-Terrestrial, The Lion King and A Bug's Life.
For me personally it's without a doubt Big Momma's House 2. Everyone knows that Martin Lawrence simply playing a man = big laughs; you don't need to be a professor of mathematics to realise that Martin Lawrence as a big fat lady (Big Momma) = HUGE laughs x infinity. It's a given that this film is uproariously, thigh-slapping funny but you may still be wondering why it's so influential. Well, without Big Momma's House and Big Momma's House 2 there may have been no Norbit and a world without Norbit would be like a world without the sun.
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