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Assuming that we are helplessly executing our genetic programming and environmental conditioning without freedom of choice then we are not truly accountable for our actions.
And since I am firm believer in freedom of choice which in my dictionary translates in to responsibility and accountability for actions one decides/chooses to make and take.
I would have to say that yes, I can blame mass murderer for his actions and choices he / she made as a conscious being; for as long as he/she is undeniably proven otherwise to be incapable of sound judgment due to some hardware/firmware. And thus the Defective model is a victim of circumstances beyond his/hers control and ought to be fix or discarded.
Otherwise I share the view point regarding the biological programming and environmental conditioning with an exception that the biological programming provides only for predispositions and potential aptitudes for one or the other thing.
While environmental conditioning ought to identify and exploit predisposition to best possible effect
It is fascinating area of research Nature v Nurture. Humans, the mind and the biology, these topics are like borderline of constantly shifting tectonic plates, we can look there but there is too much chaos to see anything. We know the materials but there is too many variants to correlate the hardware and software..
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"Each generation imagines itself to be more intelligent than the one that went before it, and wiser than the one that comes after it." 
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