Quote:
Originally Posted by Salem
Why do I get a headache everyday?
And..
If you take X amount of painkillers in one sitting, it fucks up your liver, but what about if you slowly build up a tollerance to that instead of taking 2, you have to take 4, or 6 to get the same relief as you used to with 2, does that still fuck you up?
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1: What medical conditions do you have and what medicines and supplements do you take daily?
2: Acetaminophen is the NSAID that has a tendency to cause liver damage. you cannot build a tolerance to it because its mode of toxicity is due to overloading of the glucuronide metabolic pathway by NAPQI, an extremely hepatoxic byproduct of acetaminophen metabolism. Any NAPQI in excess of what can be metabolized through the normal pathway is conjugated with glutathione. The body can produce a slight to moderate excess of both glutathione and the proteins needed for glucuronide metbolism, but not enough to produce a significant change in the liver's ability to inactivate NAPQI.
Alcohol and acetaminophen are also a deadly combination because alcohol and acetaldehyde dehydrogenation compete for the glucoronide pathway and deplete hepatic levels of glutathione, leading to a buildup of NAPQI that destroys liver tissue through oxidation.
(yes, I had to look up a few details on this one)