Well, everybody on the board can tell you "don't do this, don't do that", and it is good advice, but it won't stop you. If you're gonna do anything, first of all DON'T TRIP ALONE, you'll need someone who can show you what a normal dose of whatever you're doing is, and I'd recommend cutting that in half for a first timer. They can also help keep your mind focused if things start to go wrong.
As far as the drugs you've mentioned, I'd start with shrooms, since they're the least harmful. They taste nasty, so stuff no more than one gram in a peanut butter sandwich, and just eat it. You can also grind them up and brew tea, but you'll need honey or something sweet to cover up the godawful taste.
Within 20 mins - 1/2 hour, you'll start feeling the effects, they vary from person to person, but you'll probably get giggly, you might hallucinate, if you're nervous, it might turn into paranoia, which is why you should have friends around and be someplace safe. Expect to be under the influence for at least 5 or 6 hours, it might feel like less, or more, but the key to enjoying yourself is to keep relaxed, take a few deep breaths if you need to, get some fresh air.
Now, Ketamine, being a depressant is completely different, you shouldn't do more than 0.1g (about 1/4 to 1/5 of a vial), it can be snorted or smoked in a joint, smoking it is tricky though. Be prepared not to move for awhile. Things'll slow down, you'll probably lose the ability to speak coherently and your co-ordination and reflexes will go out the window. Doing too much will put you in what's called a K-hole, the best description I can think of is just that, like you're trapped in an infinitely deep hole, it's not that fun, try to avoid that.
I don't have too much experience with coke or speed, but the same general rules apply, be someplace safe among friends, don't do too much, drink water, and try to keep your mind in check.
I hope this didn't come across as an advertisement for drug abuse, but if you're gonna do 'em anyways, at least you'll know what to expect.
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