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For me I've found two things that were very useful:
1) Update the definitions for your various anti-virus / anti-spyware programs and then reboot and run them in Safe Mode. Often running them in regular Windows mode will not eliminate the problem as the malicious program is already loaded into memory / may be actively blocking attempts to remove it. By running it in Safe mode that problem is resolved. Realize of course that because of all the other enhancements that are turned off in Safe mode, these scans will take much longer in Safe mode
2) Use Revo Uninstaller to get rid of anything you don't want. Revo uninstaller has a great feature to uninstall a program, then remove anything that the regular un-installer that came with the program didn't remove. I've used it countless times and it helps speed up any machine.
Hope those tips help.
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