I have the 64bit R.C. running full-time on both my computer and my Wife's. I've been using it since the beta came out, and this is one rock-solid OS. It is way faster than XP Pro in 32 or 64bit. I currently have XP Pro x32 on one drive, and Win7 x64 on another. The Win7 install replaced my old XP x64 install, so I can make comparisons from experience. It's almost painful to boot up and use XP now. I absolutely despise Vista in all it's forms even with the service packs, but this is working so well I pre-ordered it for both of us.
I haven't had one 32bit app hiccup even though it's a "new" OS, and 64bit.
Keep in mind that when the "official" version is released in October, you'll have to do a clean install if you are using XP, or the pre-release versions of Win 7. That bites, but it will be worth it.
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