When you lock your knee, the joint is supporting your weight instead of muscle. The meniscus in particular does not regenerate, whereas muscle does. While walking, you also risk hyperextension if you slip or misstep.
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Originally Posted by genuinegirly
I have one exception: I lock my knees when I realize that I'm blacking out due to hypotension, I don't want to fall over, and I don't have anything sturdy to grab.
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Locking your knees compresses a particular set of nerves connected to the vagus nerve, which commonly causes fainting. You know those Funniest Videos shows where people in the military at attention, people in choirs, people at weddings, etc. faint? It's from locking their knees and triggering a vasovagal syncope.