I live in St. Louis, Missouri
Best: I was born here.
Familiarity. The traffic is nowhere near as bad as say LA or Chicago. We have a really nice zoo and some nice museums, and they are all free (for now). We have a couple of pretty decent sports teams.
Worst: We get the crap end of all weather extremes from 100 degree days with 95% humidity to bitter sub zero days. It takes
forever for trends/innovations/technologies/chain restaurants to get here. Our public transit system is all screwed up. Alot of times concerts and events completely bypass us altogether.