First of all, it depends on the state.
DUI laws vary by state, and are generally of two types: one is that the person is under the influence and the substance incapacitates them, and the other is if the drug is present in the body at all. So some states do not allow, or are trying to pass laws not to allow, people under even prescribed doses of opioids to drive.
In others, the "impaired" part is the key, and while people are generally not impaired under the influence of small prescribed doses of methadone, if someone is involved in an accident law enforcement might decide to tack that on.
So I would check the laws in your current state, and always be aware that even if one is not impaired, it doesnt mean that the law enforcement won't try to prosecute it that way in the case of an accident.
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