Um, that depends on what you mean by 'sub-sonic'
Most .22 LR Target ammo is designed to be just-barely sub sonic in order to maximize accuracy. But it still makes noise. It should cycle your weapon fine, but it will sound just like a regular .22.
You can purchase "quiet" ammunition, though I recommend you find some where the bullet weighs more than 40 grains. They use a fast burning powder so there is essentially no 'muzzle blast' when the bullet finally leaves the barrel, but due to the mass of the round, it can still do damage. They might not cycle your weapon, but it shouldn't jam up, and worst case you will have to manually cycle. Shouldn't have to worry about a squib load either.
Others, like Aguila Colibri (right name?) use no powder at all and thus rely on a very light projectile, these probably won't even feed through your magazine, definately won't cycle your action, and may get stuck in the barrel.
Edit: After reading Crompsin's post, I need to clarify, Aguila makes more than one kind of round, the stuff I am referring too is crap. Sounds like they make better rounds also.
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