yournamehere

Is this drive strictly for data?

If so, view the files "by type," and delete any files with extensions that aren't your typical data file extention (exe, cab, dll, bat, etc).

If not, then no - no difference.

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If you want to avoid 95% of internet spelling errors:
"If your ridiculous pants are too loose, you're definitely going to lose them. Tell your two loser friends over there that they're going to lose theirs, too."
It won't hurt your fashion sense, either.