Not if you've ever put any medication in the tank
I have a 75 I'm setting up right now. Thin topsoil under rocks under river sand substrate. I like a native touch to my tanks, so the sand I actually went to the river for and got in buckets, then rinsed any silt out with the water hose and my hands for mixing. I'll take a pic later, but it's not much to look at. We have native E. cordifolius (one species of amazon sword) and I know where it is
. It's surprisingly hard to find around here for some reason. It'll be a mix of native and tropical, but either way low-maintenance.