Yea, since you're not designing in multiple pages, you can avoid InDesign and Quark (though I have a habit of using InDesign whenever I'm handling type, as I don't trust myself without setting up style sheets first). If the type stays big, you can design it in photoshop and probably don't have to worry about losing resolution when you print it out. If you're writing paragraphs (like around 11-12 pt), it may get a little fuzzy, so it's safer to do it in illustrator. This is assuming you have these programs already. You can do basic, but still really clean designs in Publisher, but it's nowhere near as fun as illustrator. =)
How big of a cover do you need to design? Like Logan says, the crop marks will save you, especially if it's an odd format.
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