I have to do it.
Heath Ledger as the Joker in
The Dark Knight
Christian Bale as Patrick Bateman in
American Psycho
Sigourney Weaver as Ellen Ripley in
Alien (and
Aliens, and
Alien 3..)
Milla Jovovich as Leeloo in
The Fifth Element
Jeff Goldblum as Dr. Ian Malcolm in
Jurassic Park (known as "humans making bad choices" by Crompsin)
Sam Neill as Dr. Alan Grant in
Jurassic Park
Harrison Ford as Indiana Jones (in all of the movies!)
Anthony Hopkins in most of his roles (but most notably Dr. Lecter in
Silence of the Lambs)
...I might think of more later.