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Training has been mentioned several times, and I would just like to say that IMHO the 'Mozambique Drill' (2 shots centermass, followed by 1 in the head) is the most effective way to stop a motivated adult.
The FBI did a ballistics effectiveness study, and found that even after having their heart destroyed, about half of all suspects were still able to return fire. Some of them were even able to incapacitate or even kill the agent that shot them. This should underscore the importance of accuracy, and the headshot.
To further make this point, I know a guy (Ranger in Grenada invasion) that has personally seen a man have his hand blown completely off by fragmentation grenade, and still proceed to stab his attacker to death.
Round placement is key. Pain-as-deterrent will not save you against a determined foe.
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